False-positives in Covid-19 testing?

The Covid-19 antibody test challenge

Dr. Tobias Polifke & Dr. Peter Rauch, CANDOR Bioscience GmbH, Wangen, Germany

In the current situation of the Covid-19 pandemic, reliable IgG antibody tests are urgently needed all around the world. Virologists caution against cross-reactivities that could potentially lead to false positives.

Using ELISAs as an example, we discuss the technical requirements for the development of truly dependable immunological testing methods, since the cross-reactivities debated by many virologists constitute only a small fraction of the actual challenges.